I don’t believe we can do anything at all without side effects—also known as unintended consequences. Those consequences may be beneficial or harmful. They may be too slight to matter or they may be worth the risk because the potential benefits are great, but the consequences are always there.
A handy reminder from Octavia Butler’s essay A Few Rules for Predicting the Future; one us lowly humans so easily ignore or pretend isn’t a thing. We change things every time we wake up in the morning, and I suppose also on the day we eventually don’t.